发明名称 |
Tylosin derivatives and their manufacturing process |
摘要 |
New tylosin derivatives having at least one acyl group at the 3- and 4''-positions of tylosin, and the acid addition salts thereof, which inhibit the growth of various microorganisms including drug-resistant bacterial isolants and which produce high blood levels through oral administration are produced by a biochemical reaction using the microorganisms of the genus Streptomyces which are selected for their newly-found ability to acylate at least one of the 3- and 4''-positions of macrolide antibiotics; they are recovered from the reacted mixture by conventional methods for recovering macrolide antibiotics.
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申请公布号 |
US4092473(A) |
申请公布日期 |
1978.05.30 |
申请号 |
US19760708151 |
申请日期 |
1976.07.23 |
申请人 |
SANRAKU OCEAN CO., LTD. |
发明人 |
OKAMOTO, ROKURO;FUKUMOTO, TSUMORU;TAKAMATSU, AKIRA;TAKEUCHI, TOMIO |
分类号 |
C07H17/08;C12P19/62;(IPC1-7):A61K31/71 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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