| 发明名称 |
DNA AND RNA MOLECULES STABILIZED BY MODIFICATIONS OF THE 3'-TERMINAL PHOSPHODIESTER LINKAGE AND THEIR USE AS NUCLEIC ACID PROBES AND AS THERAPEUTIC AGENTS TO BLOCK THE EXPRESSION OF SPECIFICALLY TARGETED GENES |
| 摘要 |
<p>The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.</p> |
| 申请公布号 |
AU2782989(A) |
申请公布日期 |
1989.07.05 |
| 申请号 |
AU19890027829 |
申请日期 |
1988.10.31 |
| 申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
JOSEPH A. WALDER;ROXANNE Y. WALDER;PAUL S. EDER;JOHN M. DAGLE |
| 分类号 |
C12N15/09;A61K48/00;C07H19/00;C07H21/00;C12N15/113;C12Q1/68;G01N33/48 |
主分类号 |
C12N15/09 |
| 代理机构 |
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代理人 |
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