| 摘要 |
<p>A peptide having the amino acid sequence H-Leu-Gln-X-Arg-Ile-Leu-Ala-Val-Glu-Arg-Tyr-Leu-Lys-Asp-Y-Z-Leu-W wherein X represents a peptide bond or an amino acid residue selected from Ala, Thr, Val, Ser and Asn; Y represents a peptide bond or an amino acid residue selected from Gln, Gly, Ala and Thr; Z represents a peptide bond or an amino acid residue selected from Gln, Gly, Ala and Thr; and W represents -OH or -NH2; is described. When X represents Ala, Y represents Gln and Z represents Gln, the peptide corresponds to a part of gp41, the transmembrane protein of HIV-1 (human immunodeficency virus type 1). Furthermore, there is disclosed the above defined peptides for diagnostic use in the determination of possible development in an HIV-infected patient of a disease caused by HIV, such as LAS, ARC or AIDS; the antibodies reacting with at least one of said peptides; a method of isolating antibodies reacting with at least one of said peptides; a method of determining possible development in an HIV-infected patient of a disease caused by HIV, wherein said peptides are used; a method of detecting immunosuppressive protein produced by HIV, wherein said peptides are used; a medicament for prophylactic or therapeutic use in the prevention or treatment of a disease caused by HIV, which comprises antibodies reacting with at least one of said peptides; and a vaccine composition comprising at least one of said peptides.</p> |
