发明名称 |
EX vivo effector cell activation for target cell killing |
摘要 |
A method and composition for killing target cells is disclosed. The method utilizes ex vivo IL-2 activation of leucocyte effector cells and arming the activated leucocyte effectors with monoclonal antibodies whose Fc portions bind to the IL-2-activated effectors and whose paratopic portions immunoreact with an epitope expressed on the surfaces of the target cells. The composition contains a cytolytic amount of the armed, IL-2-activated effector cells dispersed in an aqueous physiologically tolerable diluent medium.
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申请公布号 |
US4844893(A) |
申请公布日期 |
1989.07.04 |
申请号 |
US19860916173 |
申请日期 |
1986.10.07 |
申请人 |
SCRIPPS CLINIC AND RESEARCH FOUNDATION |
发明人 |
HONSIK, CYRIL J.;REISFELD, RALPH A. |
分类号 |
C12N5/06;A61K35/14;A61K45/00;A61K47/48;C12N5/02 |
主分类号 |
C12N5/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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