摘要 |
PCT No. PCT/NL85/00045 Sec. 371 Date Jul. 10, 1986 Sec. 102(e) Date Jul. 10, 1986 PCT Filed Nov. 14, 1985 PCT Pub. No. WO86/03010 PCT Pub. Date May 22, 1986.Method for labelling amine-containing compounds like proteins with a metal, particularly technetium-99m comprising reacting metal ions in an acidic medium with a compound represented by formulae (I) or (II), wherein R1, R2 and R3 are independently selected from hydrogen, alkyl, substituted alkyl, aryl, alkanyl etc. to form a reactive intermediate compound and thereafter reacting said reactive intermediate compound with the amine-containing compound to be labeled. This kind of labeled amine-containing compounds have beneficial properties in immuno-diagnostic and therapeutic applications, particularly when they are used in vivo.
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