The pentapeptide Val Val Asn Asp Leu has been found to be the shortest peptide sequence that inhibits the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication. Longer peptides containing the foregoing pentapeptide sequence are more potent inhibitors.
申请公布号
US4845195(A)
申请公布日期
1989.07.04
申请号
US19870053179
申请日期
1987.05.22
申请人
MERCK & CO., INC.
发明人
COLONNO, RICHARD;GARSKY, VICTOR M.;HANNAH, JOHN;STEIN, ROBERT B.;TOLMAN, RICHARD L.