MED AVERMECTINER OG MILBEMYCINER BESLAEGTEDE FORBINDELSER, FREMGANGSMAADE TIL FREMSTILLING DERAF, PRAEPARATER TIL BEHANDLING OG FORHINDRING AF PARASITINFEKTIONER HOS MENNESKER OG DYR OG FREMGANGSMAADE TIL BEKAEMPELSE AF SKADEDYRSANGREB INDEN FOR LANDBRUG OG HAVEBRUG

摘要

Antiparasitic compounds of formula (I): The broken line at the 22-23 position representing an optional double bond and either R<1> is H or OH and the double bond is absent or the double bond is present and R<1> is absent; R<2> is optionally substituted phenyl, or a group of formula (II): wherein X is 0, S or -CH2-, abc and d are 0-2 and a+b+c+d is H or Me R<4> is H, OH or 4<1>-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy. The compounds are prepared by fermentation of Streptomyces avermitilis in the presence of an N-alkanoyl cysteamine thioester containing R<2>.