Glucagon fragment and utility hereof

摘要

Known glucagon fragments are not effective in producing antibodies against glucagon but the problem has been overcome using the glucagon fragment (16-29) of formula [I]: H-Ser-Arg-Ala-Gln-Asp-Phe-Val- Gln-Trp-Leu-Met-Asn-Thr-OH which peptide may be conjugated with a protein such as albumin. The conjugate may be employed to prepare antibodies against the peptide of formula [I] by administering the conjugate to a mammal to sensitise the mammal to the peptide. The antibody is also active against glucagon (1-29) and therefore may be employed to determine glucagon (1-29) by contacting a glucagon- containing sample with the said antibody.