HUMAN CELL LIFE EXTENSION

摘要

Human differentiated cells are modified but not transformed using the Ela region of adenovirus or an expression system for SV40 T-antigen. The modified cells have reduced doubling times and are capable of an increased number of passages, while retaining their ability to generate a desired product, such as t-PA. Therefore, the modified cells are useful for the large-scale production of factors natively or recombinantly produced.