摘要 |
The present invention relates to novel 2,6-methanopyrrolo-3-benzazocines, of formula <CHEM> wherein R<1> is hydrogen, alkyl, alkenyl, cycloalkylalkyl, arylalkyl or -C(O)R<9> wherein R<9> is hydrogen, alkyl or alkoxy; R<2> and R<3> are independently alkyl, arylalkyl, halogen, oxo or -C(O)R<7> wherein R<7> is hydrogen, alkyl, aryl, arylalkyl, hydroxy, alkoxy, arylalkoxy, aryloxy or amino; R<4> is hydrogen, alkyl, arylalkyl or -C(O)R<8> wherein R<8> is hydrogen, alkyl, arylalkyl, aryl, alkoxy, arylalkoxy or aryloxy; R<5> and R<6> are independently hydrogen or alkyl, or taken together are a bivalent radical of the formula -(CH2)4-; m, n, and p are integers independently having values of zero or 1, Y is halogen or alkyl; and the dotted line in said compound is an optional bond. The compounds have analgesic activity. |