N-(2-Alkyl-3-mercapto-1,5-di-oxoalkyl)glycinamide derivatives and their use as collagenase inhibitors.

摘要

Novel compounds of the formula (I), a process for their preparation and their use as collagenase inhibitors are described: <CHEM> in which,R1 is hydrogen, alkyl, or optionally substituted aryl; R2 is hydrogen, or acyl such as - @-alkyl or - @ - Z where Z is optionally substituted aryl; R3 is C3-6 alkyl; R4 is hydrogen, alkyl, -CH2-R10 where R10 is optionally substituted phenyl or heteroaryl, or a group <CHEM> where R11 is hydrogen, alkyl, or -CH2-Ph where Ph is optionally substituted phenyl, and R12 is hydrogen or alkyl; and R5 is hydrogen, alkyl, or a group <CHEM> where R13 is hydrogen, or alkyl, and R14 is hydroxy, alkoxy, or -NR6R7, where each of R6 and R7 is hydrogen or alkyl, or R6 and R7 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-membered ring with an optional oxygen or sulphur atom in the ring or an optional further nitrogen atom optionally substituted by alkyl.