发明名称 Tc99m-Phenida, radioscintigraphic agent for diagnosis of hepatoniliary disease
摘要 This invention relates to novel derivatives of imino diacetic acid of the formula: <IMAGE> wherein R1 is selected from the group consisting of: <IMAGE> <IMAGE> +TR <IMAGE> wherein X is halo (chloro, bromo or iodo) and R2 is lower alkyl of from 1-5 carbon atoms. It also relates to a novel diagnostic kit for hepatobiliary imaging comprising ingredients employed in the intravenous injection of a complex of technetium 99m, and an imino diacetic acid of the above formula. It also relates to a process for preparing said compounds by reaction of nitrilotriacetic acid anhydride and an amine of the formula R1NH2 wherein R1 is as defined hereinabove.
申请公布号 US4454107(A) 申请公布日期 1984.06.12
申请号 US19820412747 申请日期 1982.08.30
申请人 MERCK & CO., INC. 发明人 ROLLESTON, RICHARD E.
分类号 C07D277/66;A61K51/00;A61K51/04;C07C231/14;C07C237/04;C07D265/32;C07D277/82;(IPC1-7):A61K43/00;A61K49/00 主分类号 C07D277/66
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