摘要 |
Piperazine derivs. of formula (I) are prepd. by reacting a cpd. of formula (II) with a cpd. of formula (III). In the formulas, Het is an opt. substd. 2-, 3- or 4-pyridyl gp., or 2-imidazolyl gp.; R is - NHSO2R3, -SO2NR1R2, nitro, amino or acetamido; R3 is C1-4 alkyl, C3-7 cycloalkyl or -NR1R2; R1 and R2 are each H or C1-4 alkyl; X is - (CH2)m-, -CO(CH2)n- or -CH(OH)(CH2)n; m is 1-4; n is 1-3; Q is a leaving gp.. (I) are useful as antiarrhythmic agents.
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