| 摘要 |
Disclosed are novel carboxyalkyl dipeptides which are useful as inhibitors of angiotensinconverting enzyme and as antihypertensive agents, having the formula …<CHEM>… and the pharmaceuticallv acceptable salts thereof, wherein R and R<6> are for example hydroxy, lower alkoxy or aryllower-4 alkoxy; R<1> is for example hydrogen, alkyl, lower alkoxy or aryloxy; R<2> and R<7> are the same or different and are hydrogen or lower alkyl; R<3> is for example lower alkyl or phenyl lower alkyl; R<4> and R<5> are selected from hydrogen, lower alkyl and Z, or R<4> and R<5> taken together form a group represented by Q, U, V, Y, D or E wherein …<CHEM>… wherein X<1> and X<2> independent of each other are O, S or CH2, R<8> and R<9> independent of each other are lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl having 3 to 8 carbon atoms, hydroxy lower alkyl or -(CH2)nAr, wherein n is 0, 1. 2 or 3 or R<8> and R<9> taken together form a bridge W, wherein W is a single bond or a methylene bridge or a substituted methylene bridge when at least one of X<1> and X<2> is methylene, or W is an alkylene or substituted alkylene bridge having 2 or 3 carbon atoms; with the proviso that at least one of R<4> and R<5> is Z; …<CHEM>… wherein L is O or S.… The compounds can be prepared according to known methods such as for example by condensation of an aminoacid XXI with an aminoacid XVII …<CHEM>… |
