| 摘要 |
PURPOSE: To obtain a medicine for treatment of cancer, containing vincristine and a peptide or an N-acryl derivative thereof, useful for the treatment of cancer, especially for suppressing Hodgkin's disease and other blood cancers without a fear of any complication. CONSTITUTION: This material containing vincristine, contains vincristine or a salt thereof, a peptide of formula I [Met(X) is an amino acid group of Met, Met(O), MetO2 or Met(O2 ); A is an amino acid group of L-lys, D-Lys, L-Arg, etc.; B is an amino acid group of L-Trp or L-Phe; Y is Gly-Z or Z (Z is hydroxyl, an esterified hydroxyl or a substituted amino) or a salt thereof, or an N-acyl derivative thereof. The objective material is obtained by preferably preparing the above mixture to a form of an injectable agent by a usual method. It is preferable to blend 0.5-2mg/ml vincristine with 10<-4> -2×10<-3> mmol peptide of the formula or the N-acryl derivative. |
