发明名称 |
Amino anthracenediones-bis platinum complexes, useful as antitumoral agents. |
摘要 |
<p>Bis-platinum complexes of formula I <CHEM> wherein A is a disubstituted 1,4-anthracenedione; X, X min are ligands selected from the group consisting of Cl, Br, OH, CH3 SOCH3.OH or CH3SOCH3.Hal or, taken together, form the anion of a dicarboxylic acid; m is zero, 0.5 or an integer from 1 to 5; Solv is a solvent of crystallization; Ra is hydrogen, alkyl optionally substituted by hydroxy groups and/or interrupted by oxygen atoms; Rb is alkyl optionally substituted by hydroxy, alkoxy, polyalkoxy or sulphonic groups or a residue of an amino-sugar and n is an integer from 2 to 3. Compounds I are useful as anti-tumor agents.</p> |
申请公布号 |
EP0320960(A1) |
申请公布日期 |
1989.06.21 |
申请号 |
EP19880121072 |
申请日期 |
1988.12.16 |
申请人 |
BOEHRINGER BIOCHEMIA ROBIN S.P.A. |
发明人 |
PASINI, ALESSANDRO;ZUNINO, FRANCO;TOFANETTI, ODOARDO;GANDOLFI, CARMELO A.;TOGNELLA, SERGIO;SPINELLI, SILVANO |
分类号 |
A61K31/28;A61K31/282;A61K31/70;A61K31/7135;A61P35/00;C07F15/00;C07H23/00 |
主分类号 |
A61K31/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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