| 摘要 |
PURPOSE:To obtain a remedy for hepatic disease, by using a cyclic sulfur- containing compound as an active component. CONSTITUTION:The objective agent can be produced by using a cyclic sulfur- containing compound of formula (the dotted bond may be present or absent) (i.e. 1,3-dithiol-2-thione or 1,3-dithiolane-2-thione) as an active component and converting into a drug by conventional method as necessary using an excipient, a binder, a disintegrant, a lubricant, etc. It can be used in the form of tablet, granule, powder, capsule, suspension, injection, suppository, etc. The daily dose of the agent is 0.01-50mg per 1kg of body weight for oral administration and 0.002-10mg for parenteral administration. It has remarkably high safety and suppressing effect for hepatopathy compared with malotilate known as a drug effective against hepatocirrhosis.
|
