| 摘要 |
Compounds of the formula A-B-C-D in which A, B, C and D have the meaning indicated in Claim 1, their preparation and therapeutic compositions containing them for use against pain, in particular for the treatment of migraine, as antiarrhythmics and for the treatment of gastrointestinal disorders such as gastric secretion disorders, gastritis, peptic ulcer, dyskinesia of the biliary tract, spastic colon, irritable colon, Crohn's disease, ulcerative colitis, carcinoid syndrome and diarrhoeas of varied genesis (e.g. bacterially caused diarrhoeas, cholangenic diarrhoea, psychogenic diarrhoea) and for the improvement of stomach emptying, for the treatment of gastroduodenal reflux and gastrooesophageal reflux, of oesophageal motility disorders, achalasia, hiatus hernias, cardiac insufficiency, hypotonia of the stomach, pylorus hyperplasia, paralytic ileus, Hirschsprung's disease, and also for the treatment of anxiety states, of psychiatric disorders such as social withdrawal symptons, manic-depressive psychoses, psychoses and other illnesses connected with stress, disorders of the state of alertness such as geriatric syndromes, and also for the treatment of rhinitis, pulmonary embolism and for the improvement of nasal absorption of other active compounds, e.g. of peptides, as well as the inhibition of emesis caused by cytostatics.
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