发明名称 |
METHOD OF INHIBITING THE ACTIVITY OF LEUKOCYTE DERIVED CYTOKINES |
摘要 |
A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, or activity or other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of formula (I) in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals other than a 3-methyl-3-hydroxy butyl radical, 3-methyl-3-hydroxy pentyl radical, or 4-methyl-4-hydroxy pentyl radical, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. The inhibition of IL-1, TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions. |
申请公布号 |
WO8905145(A1) |
申请公布日期 |
1989.06.15 |
申请号 |
WO1988US04375 |
申请日期 |
1988.12.07 |
申请人 |
HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED;THE UNIVERSITY OF VIRGINIA |
发明人 |
MANDELL, GERALD, L.;SULLIVAN, GAIL, W.;NOVICK, WILLIAM, J., JR. |
分类号 |
C07D473/04;A61K31/52;A61K31/522;A61P29/00;A61P37/06;C07D473/06;(IPC1-7):A61K31/52 |
主分类号 |
C07D473/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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