TIGOGENIN-CELLOBIOSIDE AND ITS HEPTAACETATE, METHODS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING TIGOGENIN-CELLOBIOSIDE

摘要

Tigogenin cellobioside is a potent inhibitor of cholesterol absorption and therefore useful in treating hypercholesterolemia and arteriosclerosis. Tigogenin cellobioside heptaacetate is useful as an intermediate in preparing tigogenin cellobioside. The two compounds are represented by the formula wherein R is hydrogen or -C(O)CH3, either as a mixture of the alpha - and beta -anomers or as the individual alpha - or beta -anomer.