| 摘要 |
<p>This invention relates to gold (III) complexes comprised of a nitrogen containing ligand and chloride or bromide. This invention also relates to pharmaceutical compositions which contain one or more of said complexes as an active ingredient and to a method for the treatment of tumors via the administration of same. Aminegold complexes are disclosed in the literature but none of these have proven to be clinically useful in the treatment of tumors; therefore, this invention constitutes an advance in the art because it adds to the known family of anti-tumor agents a new and rationally developed class of aminegold(III) complexes. The discovery that Cisplatin is effective against human cancers aroused interest initially in precious metal complexes as a source of anti-tumor agents. Although many new platinum compounds have been shown to be useful in the treatment of tumors and although some gold complexes are used in the treatment of arthritis, (D.H. Brown, et al; Chemical Society Reviews, Vol. 9: page 217-240 (1980)) there is no evidence in the literature to suggest that trihalo(amine)gold(III) complexes can be used as anti-tumor agents. Accordingly, there is a need for gold complexes which exhibit anti-tumor activity and which can be administered orally or parenterally.</p> |
