| 摘要 |
<p>The invention relates to transdermal drug patches for the controlled release of drugs to the human skin, comprising a covering layer connected to which is an adhesive film insoluble in water made of a rubber and adhesive resin material in which the drug or drugs are wholly or partially soluble and a detachable protective layer which covers the adhesive film, which is characterised in that the drug or drugs in the rubber and adhesive resin material are present together with a polymer capable of swelling in water and insoluble in the adhesive film, the quantity of polymer being between 3 and 30% by weight of the rubber and adhesive resin mixture. By the incorporation of this particular water-swellable polymer material in the rubber/adhesive resin mixture together with the drug which polymer material is insoluble in the matrix, in a particular proportion calculated to the weight of the rubber and adhesive resin material in particular the drug release from the patch to the skin is increased to twice or even more is achieved.</p> |
