FREMGANGSMAATE TIL FREMSTILLING AV OPTISK AKTIVE 3-DESMETYLMEVALONSYREDERIVATER SAMT MELLOMPRODUKTER.

摘要

A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I I (3,5-dihydroxy carboxylic acid derivatives) or of the formula II II ( beta -hydroxy lactones) in which R, R1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII XII in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.