| 摘要 |
A flexible, sheet-like, sustained release medicament device for orally administering a predetermined selective dose of a medicament and a method of preparing the device is disclosed. The device is of a multilayer composite construction comprising (a) at least one carrier film comprising at least one water-insoluble polymer and containing medicament, and (b) at least one barrier film overlaying said carrier film on at least one surface thereof and sealed to said carrier film along its periphery and in such a way as to entrap small quantities of air between said carrier and barrier films, said barrier film comprising at least one water-insoluble and water- and medicament-permeable polymer or copolymer, said multilayer composite construction having a bulk density of less than 1.0 g/cc, so as to render the sustained release medicament device buoyant in the gastric juices of the stomach, and being facilely divisible into any desired length. |
