摘要 |
Molecular structures of beta -adrenergic antagonists are modified to produce biologically active compounds. The beta -antagonists are modified to form molecules of the general structure: <IMAGE> wherein R is most generally R''-OCH2-, and in some instances is R''-, and R''=an aryl or substituted aryl moiety; R'=-H, -CH3, or a short chain alkyl moiety; and Y=-OH, or more usually, -OAX or -NHAX, where A=an alkyl, aryl, or aralkyl moiety, and X=a terminal grouping, such as -CH3, -CF3 or -(CH2)nCOOH; or AX may be a carrier moiety consisting of a defined peptide or protein.
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申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
GOODMAN, MURRAY;MARR-LEISY, DEBRA;ROSENKRANZ, ROBERTO P.;MELMON, KENNETH L.;VERLANDER, MICHAEL S. |