PHOSPHORUS-CONTAINING 3-HYDROXY-3- METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR, ITS NOVEL INTERMEDIATE AND USE THEREOF

摘要

Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure wherein R is OH, or salts thereof or lower alkoxy; R is H or alkyl; X is -CH2-,-CH2-CH2-,-CH=CH-, -C IDENTICAL C-, -CH2CH2CH2- or -CH2O- (where O is linked to Z); Z is a hydrophobic anchor, such as wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.