摘要 |
Amino-4 trifluoromethyl-1 tetraline derivatives of general formula (I) in which: X is an aromatic nucleus, in particular phenyl, naphtyl or thienyl, which may carry one or two substituents chosen from halogen, hydroxy, C1 to C8 alkoxy or trifluoromethyl, R1 is a hydrogen or halogen atom, a hydroxy or a C1 to C8 alkoxy group, occupying one of the 5, 6 or 7 positions or a methylene dioxy group, occupying the 5 and 6 or 6 and 7 positions, R2 is a hydrogen or halogen atom, a hydroxy group, a C1 to C8 alkoxy group, occupying one of the other 5, 6 or 7 positions, and R3 and R4 are each a hydrogen atom, a methyl group or a straight or branched C1 to Cn alkyl group, where n is 2 or more, possibly halogenated, hydroxylated, or aminated, or R3 and R4, taken together with the nitrogen atom to which they are attached form a saturated heterocycle, possibly substituted, with five or six atoms, one or two of which are heteroatoms chosen from nitrogen, oxygen or sulphur. Drug. |