PROSTACYCLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES

摘要

1. 5-Cyanoprostacyclines of the general formula I see diagramm : EP0130142,P10,F2 wherein A represents a _t_r_a_n_s-CH = CH- or -C -= C- group, W represents a hydroxymethylene, acetoxymethylene, see diagramm : EP0130142,P10,F3 wherein the OH or acetoxy group may have the alpha- or b¢eta-configuration, D and E together represent a direct bond or D represents a straight-chained alkylene group having from 1 to 5 C atoms or a branched alkylene group having from 2 to 5 C atoms, E represents an oxygen atom, a -C -= C- bond or a direct bond, R2 represents a C1 -C7 -alkyl group or phenyl, R1 represents a hydroxy or acetoxy group and R3 represents the acetal radicals see diagramm : EP0130142,P11,F1