NEW AVERMECTIN DERIVATIVES,A PROCESS FOR THEIR PREPARATION AND THEIR USE

摘要

The present invention relates to novel avermectin derivatives of the formula I …… in which… R<1> represents hydrogen, OH, C1-5-alkanoyloxy, alpha -L-oleandrosyloxy, alpha -L-oleandrosyl- alpha -L-oleandrosyloxy, 4'-C1-5-alkanoyl- alpha -L-oleandrosyloxy, 4''-C1-5-alkanoyl- alpha -L-oleandrosyl- alpha -L-oleandrosyloxy,… R<2> represents hydrogen, OH, C1-5-alkanoyloxy, R<2> represents hydrogen when a double bond exists between C22 and C23,… R<3> represents straight-chain or branched alkyl or alkenyl,… R<4> represents hydrogen, OH, C1-5-alkanoyloxy, heterocyclylcarbonyloxy, the bond between the C atoms C22 and C23 being a single or a double bond, and it being possible for the double bond of the cyclohexene ring to be between the C atoms C3 and C4 or between the C atoms C4 and C5,… their preparation, intermediates for carrying out these processes, and their use as parasiticides.