Azacyclic compounds and their preparation and use.

摘要

Novel azacyclic compounds selected from the group consisting of <CHEM> wherein R<1> is H or C1-6-alkyl <CHEM> wherein R min is C3-8-alkyl, cyclopropyl, C4-8-cycloalkyl, benzyl which may be substituted, or C1-4-alkoxy-C1-4-alkyl, and R sec is H or C1-8-alkyl or C1-6-alkoxy or C1-4-alkoxy-C1-4-alkyl or aryl, and R''' is H or C1-6-alkyl or C4-8-cycloalkyl; and R<4> is H, C1-8-alkyl or Cl; and <CHEM> provided that R<3> is not <CHEM> wherein R min is C3-8-alkyl, cyclopropyl or C1-3-alkoxymethyl, and provided that R<3> is not -CH=N-OR''', wherein R''' is H or C1-6-alkyl, when the compounds of formula I is <CHEM> and a salt thereof with a pharmaceutically-acceptable acid. The new compounds are useful in improving the cognitive functions of the forebrain and hippocampus of mammals, and are useful in the treatment of Alzheimer's disease.