发明名称 PROCESS FOR PREPARING N-(DIBENZYLOXYPHOSPHORYL)-CYANAMIDE AND PROCESSES USING SAID COMPOUNDS AS INTERMEDIATE FOR THE SYNTHESIS OF PHOSPHAGEN SUBSTANCES
摘要 The invention relates to a process for preparing compounds of general formula: <CHEM> wherein R = Hydrogen, halogen, alkyl, nitro-group; said compounds, which are indicated hereinunder with the general term <<N-(dibenzyloxyphosphoryl)-cianamide>> are useful as intermediates in the synthesis of phosphagen compounds such as phosphocreatine, phosphocreatinine and similar compounds. Such process is characterized in that dibenzyloxyphosphoryl chloride is reacted with cyanamide, N-(dibenzyloxyphosphoryl)-cyanamide being produced; this latter can react with substances provided with a primary or secondary amine function, to give the corresponding guanidinoderivatives; e.g., with a sarcosine derivative to give N-(dibenzyloxyphosphoryl)-creatine or N-(dibenzyloxyphosphoryl)-creatinine.
申请公布号 DE3569531(D1) 申请公布日期 1989.05.24
申请号 DE19853569531 申请日期 1985.01.25
申请人 F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. 发明人 GUERRATO, ALFREDO;RIZZI, AMLETO VIA CALESELLA 65
分类号 C07F9/24;C07F9/6506;(IPC1-7):C07F9/24;C07F9/65 主分类号 C07F9/24
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