Phenethanolamine derivatives.

摘要

The invention provides compounds of the general formula (I) and physiologically acceptable salts and solvates thereof, wherein Ar represents the group where Q<1> represents a straight or branched C1-3alkylene group, where Q<2> represents a group R<3>CO-, R<3>NHCO-, R<3>R<4>NSO2- or R<5>SO2-, where R<3> and R<4> each represent a hydrogen atom or a C1-3alkyl group, and R<5> represents a C1-3alkyl group, R represents a hydrogen atom or a C1-3alkyl group; R<1> and R<2> each independently represent a hydrogen atom or a methyl or ethyl group; and k represents an integer from 1 to 8; m represents zero or an integer from 2 to 7, and; n represents an integer from 1 to 7 with the proviso that the sum total of k, m and n is 4 to 12; X represents an oxygen or sulphur atom, and; Y and Z each represent a bond, or an oxygen or sulphur atom with the proviso that when Y is a bond m is zero, or when Y represents an oxygen or sulphur atom m is an integer from 2 to 7, or when Y and Z each independently represent an oxygen or sulphur atom then n is an integer from 2 to 7; Q represents a naphthalenyl group which may optionally be substituted by one or two groups selected from C1-4alkyl, C1-4alkoxy, hydroxy and halogen. The compounds have a stimulant action at beta 2-adrenoreceptors and may be used in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.