| 摘要 |
1,2-Diaminocyclohexane platinum (II) complexes of the general formula: <IMAGE> (I) wherein R1 and R2, are selected from nitrate and various organic carboxylate groups, with the proviso that R1 and R2 are not both nitrate, and the configuration of the 1,2-diaminocyclohexane being selected from cis, trans-d and trans-1, have been found to exhibit potent cytostatic activity. They may be made by reacting a starting material, in which R1 and R2 are nitrate, with the appropriate carboxylic acid or salt thereof. |
