发明名称 |
FREMGANGSMAADE TIL FREMSTILLING AF INSULINER UD FRA TILSVARENDE PRAEPROINSULINANALOGE |
摘要 |
<p>The invention relates to a process for the preparation of insulins from analogs of preproinsulins, which comprises reacting preproinsulin analogs, at a pH below the isoelectric point of the insulins in the presence of trypsin or a trypsin-like endopeptidase, with an ester of natural amino acids or their derivatives and then cleaving off the ester group and other protective groups which may optionally be present.</p> |
申请公布号 |
DK154573(C) |
申请公布日期 |
1989.05.22 |
申请号 |
DK19830001178 |
申请日期 |
1983.03.11 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
OBERMEIER, RAINER;GEIGER, ROLF;GRAU, ULRICH |
分类号 |
C12P21/02;C07K14/62;(IPC1-7):C12P21/02 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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