ALKOXYDERIVATE VON GINKGOLIDEN, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL

摘要

The reaction of an excess of a diazoalkane with Ginkgolide A, B, C, J or M in a solvent gives a mixture of the 1-alkoxy and 10-alkoxy derivatives of that Ginkgolide. The mixture can be separated to give the individual derivatives, which are of interest in the treatment of PAF-Acether induced maladies. Methoxy and ethoxy derivatives are preferred. Pharmaceutical compositions containing the alkoxy-Ginkgolide derivatives are also disclosed.