| 摘要 |
The present invention involves a process for inducing resistance of an individual to infection by human immunodeficiency virus. The process involves vaccinating said individual with a synthetic peptide of mixture of peptides. The synthetic peptide(s) comprises an amino acid sequence derived at least in part from human immunodeficiency virus envelope protein conserved region. Upon antigenic presentation to an animal, this peptide induces directed cell-mediated immunity (i.e., T-cell cytotoxicity) to a substantially greater extent than production of antibody directed against native human immunodeficiency virus is elicited. The vaccine of the present invention comprises a synthetic peptide having an amino acid sequence derived at least in part from T-cell epitopes of human immunodeficiency virus envelope protein conserved region and preferably consists exclusively of T-cell epitopes. |
