| 摘要 |
<p>NEW MATERIAL:A compound shown by formula I (R<1> is H, alkyl, alkenyl, alkynyl or phenylalkyl; R<2> and R<3> are H, alkyl, cycloalkyl, pyridyl or phenoxyalkyl or R<2> and R<3> together with bonded N form 5-9-membered heterocyclic ring; A is alkylene; n is 0 or 1; R<4> is H, alkyl, phenyl, alkoxy or halogen; bond of carbostyril skeleton at the 3- and 4-positions is double or single bond) and a salt thereof. EXAMPLE:3-(1-t-Butylamino-1-phenylmethyl)-8-methylcarbostyril. USE:An antiarrhythmic agent suppressing irritation forming abnormality occurring in ischemia almost without influencing contractive force of cardiac muscle. PREPARATION:For example, a compound shown by formula II (X is halogen) is reacted with an amine shown by formula III to give a compound shown by formula I.</p> |
