| 摘要 |
NEW MATERIAL:An ester of 4-amino-5-fluoro-2-nitrophenoxyacetic acid of formula I (R is lower alkyl). EXAMPLE:Methyl 4-amino-5-fluoro-2-nitrophenoxyacetate. USE:A starting substance for preparing 2-[4-substituted-7-fluoro-2H-1,4- benzoxazine-3(4H)-one-6-yl]-4,5,6,7-tetrahydro-2H-indole-1,3-dione of formula II (R' is alkyl, alkenyl, alkinyl, alkoxyalkyl). PREPARATION:Esterification using 4-acetylamino-5-fluoro-2-nitrophenoxyacetic acid of formula III and an alcohol of the formula: ROH is carried out in a solvent such as methanol in the presence of an acid such as sulfuric acid, hydrochloric acid, p-toluenesulfonic acid or methanesulfonic acid at 50-200 deg.C for 10min-24hr, and simultaneously deacetylation is effected to give the compound of formula I. |
