1,2,4-BENZOTHIADIAZINE-OXIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

1,2,4-Benzothiadiazine oxide derivatives of the general formula I (I) in which R1 represents a unsubstituted or substituted aryl radical, R2 and R5, which may be the same or different, and represent hydrogen, halogen or a nitro group and R3 represents a hydrogen atom or a hydroxy radical, an alkyl, alkoxy alkyl or alkoxy carbonyl radical with up to 4 carbon atoms, unsubstituted or substituted by halogen, hydroxy, amino, alkyl amino or dialkyl amino radicals, or a phenyl radical, unsubstituted or substituted by halogen, are described; a further subject is an analogy method for the preparation of these compounds. The compounds of general formula I prepared in accordance with the method possess valuable pharmacological properties, in particular they are distinguished by remarkable anxiolytic effects on the central nervous system.