发明名称 |
Pyrrolizidine compounds, and their use as antiarrhythmic agents |
摘要 |
A novel pyrrolizidine compound of the formula <IMAGE> wherein R1 is an alkyl group of 1 to 4 carbon atoms or a phenyl group; and R2 and R3 are such that at least one of them is an alkyl group of 1 to 4 carbon atoms and the other, if not alkyl, being a hydrogen atom is produced by reacting DELTA 4(8)-dehydropyrrolizidine with a substituted malonic acid and the thus formed 2-substituted-8-pyrrolizidineacetic acid with a substituted aniline. The products are subjected to optical resolution and are potentantiarrhythmic agents.
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申请公布号 |
US4831049(A) |
申请公布日期 |
1989.05.16 |
申请号 |
US19850751797 |
申请日期 |
1985.07.03 |
申请人 |
SUNTORY LIMITED |
发明人 |
MIYANO, SEIJI;SUMOTO, KUNIHIRO;SATOH, FUMIO |
分类号 |
A61K31/40;A61P9/06;C07D487/04 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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