| 摘要 |
1-Ethyl 6-fluoro 4-oxo 7-morpholinyl 1,4-dihydro quinoline 3-carboxylic acid, of formula (I) with powerful anti-microbial activity esp. against gram-negative germs, is made by reaction of 1-ethyl 6-fluoro 7-chloro 4-oxo 1,4-dihydro quinoline 3-carboxylic acid (II) with morpholine at around 140 deg.C for around 5 hours.
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