VITAMIN D3 DERIVATIVES HAVING A SUBSTITUENT AT 2-POSITION

摘要

A1 alpha -hydroxy vitamin D3 derivative of the formula:

where R1 is a hydroxyl group, an amino group or the group: OR min (where R min is a lower alkyl group having 1 to 7 carbon atoms that may or may not be substituted by a hydroxyl group, a halogen atom, a cyano group, a lower alkoxy group having 1 to 3 carbon atoms, an amino group, or an acylamino group); R2 is a hydrogen atom or a hydroxyl group), and a process for preparing the same are disclosed.
The compounds represented by the formula above are effective for calcium control and for induction of differentiation in tumor cells and, thereofor, are useful as antitumor agents and a medicine for treating calcium dysbolism-caused diseases.