发明名称 |
4-phenyl-4-(N-(phenyl)amido) piperidine derivatives. |
摘要 |
<p>Compounds of the formula: <CHEM> and/or pharmaceutically acceptable acid addition salts thereof, in which formula: R<1> is phenyl; R<2> is phenyl unsubstituted or substituted with one or more halogens; R<3> is a lower alkyl, a lower cycloalkyl or a lower alkoxy lower alkyl group; and L is a lower alkenyl group or a substituted lower alkyl group which is thienyl lower alkyl; thiazolyl lower alkyl; [4-(lower alkyl) thiazolyl] lower alkyl; (4,5-dihydro-5-oxo-1H-tetrazol-y-1-yl) lower alkyl; [4-(lower alkyl) 4,5-dihydro-5-oxo-1H-tetrazol-1-yl] lower alkyl; 1H-pyrazolyl lower alkyl; 2-(2-dihydro-2-oxo-3H-benzoxazol-3-yl) lower alkyl; pyridyl lower alkyl; [(2-lower alkyl)5-nitro-1H-imidazol-1-yl] lower alkyl; [4-(halo) 1H-pyrazolyl] lower alkyl substituted in the 4 position by a halogen; lower cycloalkyl lower alkyl or phenyl lower alkyl have analgesic properties.</p> |
申请公布号 |
EP0315405(A1) |
申请公布日期 |
1989.05.10 |
申请号 |
EP19880310259 |
申请日期 |
1988.11.01 |
申请人 |
BOC, INC. |
发明人 |
KUDZMA, LINAS V.;SPENCER, H. KENNETH;SEVERNAK, SHERRY A. |
分类号 |
C07D211/26;A61K31/4427;A61K31/4433;A61K31/445;A61K31/4465;A61K31/4468;A61K31/451;A61P23/02;A61P25/02;A61P25/04;C07D211/58;C07D211/72;C07D401/06;C07D409/06;C07D413/04;C07D413/06;C07D417/06 |
主分类号 |
C07D211/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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