DNA coding for endothelin and use thereof.

摘要

(1) a DNA sequence containing a DNA segment coding for porcine or human endothelin, (2) a precursor protein of porcine or human endothelin, (3) a transformant bearing a DNA sequence containing a DNA segment coding for percine or human endothelin, and (4) a method for preparing mature porcine or human endothelin or a porcine or human endothelin precursor are disclosed. The cells gene-infected or transformed with the DNA of the present invention can allow a large amount of endothelin to be produced, even in various cells in which little or no endothelin is originally produced. Therefore, the production of endothelin can be advantageously achieved. Endothelin can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.