| 摘要 |
NEW MATERIAL:A compound of formula I [R<1> is H, phenylcarbonyl which may have 1-3 substituents selected from lower alkanoyl, furoyl, pyridylcarbonyl, lower alkansulfonyl, lower alkoxycarbonyl, or lower alkoxy or a lower alkylene- dioxy; R<2> is H, lower alkoxy; the bond between carbon atoms. between the 3 and 4 positions in the carbostyril skeleton] and its salts. EXAMPLE:6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbosty ril. USE:For example, heat muscle contraction enhancer (positively inotropic agent) which is used as a heart stimulant for treating cardiopathy such as congestive heart failure, with scarce increase of the pulse rate, and coronary blood flow increaser. PREPARATION:The cyclization of a compound of formula II (R<3> is H, lower alkanoyl; R<4> is H, lower alkyl; formula III is single or double bond) gives the compound of formula I. |
