发明名称 |
Phospholipase A2 inhibiting compositions and their use. |
摘要 |
<p>Inhibitors of phospholipase A2 activity at the cell-surface membrane whose molecular structure comprises a cell-permeable PLA2-inhibitor moiety covalently bonded directly or indirectly to a physiologically acceptable carrier moiety which is effective to inhibit cell internalisation of the cell-permeable PLA2-inhibitor moiety, with the proviso that phosphatidylserine is not bonded indirectly via divalent dodecanedioyl to dextrane hydrazide.</p> |
申请公布号 |
EP0315349(A1) |
申请公布日期 |
1989.05.10 |
申请号 |
EP19880309996 |
申请日期 |
1988.10.24 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM |
发明人 |
YEDGAR, SAUL;DAGAN, ARIE |
分类号 |
C12N9/99;A61K31/00;A61K31/215;A61K31/685;A61K31/74;A61K47/30;A61K47/48;A61P7/02;A61P29/00;A61P43/00;C07F9/10;C07K14/00;C07K14/81;C08B31/00;C08B37/02;C08B37/04 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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