发明名称 |
Immunogenic conjugates comprising cyclosporins. |
摘要 |
Immunogenic conjugates comprising a carrier coupled to a cyclosporin having an activate coupling group, e.g. activated carboxy group, e.g. (i) [(O-succinimidooxysuccinyl)-Thr]<2>-Cyclosporine and (ii) [(N- epsilon -succinimidooxysuccinyl)-(D)Lys]<8>-Cyclosporine. The subject conjugates are useful for the generation of monoclonal antibodies capable of distinguishing between cyclosporins, e.g. Cyclosporine, and metabolites, e.g. Cyclosporins 17 and 18. |
申请公布号 |
EP0314862(A1) |
申请公布日期 |
1989.05.10 |
申请号 |
EP19880104792 |
申请日期 |
1985.09.27 |
申请人 |
SANDOZ AG;SANDOZ-PATENT-GMBH;SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. |
发明人 |
ROSENTHALER, JOACHIM;WENGER, ROLAND;BALL, PHILIPP E.;SCHREIER, MAX H.;QUESNIAUX, VALERIE |
分类号 |
G01N33/53;A61K;C07K;C07K7/64;C07K14/00;C07K14/005;C07K14/195;C07K16/00;C07K16/44;C07K19/00;C12N;C12N5/00;C12N5/10;C12N15/00;C12N15/02;C12P;C12P21/00;C12P21/08;C12Q;C12R1/91;G01N;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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