| 摘要 |
PURPOSE:To obtain a relieving agent containing a specific organoaluminum compound as an active ingredient for nephrotoxicity caused by cyclosporin administered in kidney transplantation. CONSTITUTION:The above relieving agent containing a compound expressed by the formula [R1-R3 are H, lower alkyl, phenyl, etc.; X is OH, O-lower alkyl, amino or O<->Y<+> (Y is Na, K or compound, such as lysozyme or basic amino acid, having basic group)] as an active ingredient. This relieving agent is capable of reducing strong nephrotoxicity of cyclosporin without impairing immunosuppressive effects thereof administered in kidney transplantation. The administration form of the above-mentioned relieving agent may be oral or parenteral and can be adjusted to that of the cyclosprin. The dose thereof is preferably 20-200mg/kg/day.
|
