| 摘要 |
Compounds of the formula <IMAGE> in which Y is <IMAGE> X is O or S; Z is -CHOH-CH2-CHOH-CH2-COOH, an ester or salt thereof or the lactone thereof; and each of R1, R2 and R3 can be alkyl, cycloalkyl; or substituted or unsubstituted phenyl; and additionally R3 can be hydrogen, are obtained by a multi-step process and are useful in the treatment of atherosclerosis, e.g. sodium(E)-7-(4-phenyl-2-isopropyl-5-phenylthien-3-yl)-3,5-dihydroxyhep t-6- enoate.
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