| 摘要 |
A description is given of conjugates of vinca alkaloid of the indole-dihydroindole type with a protein or a protein fragment, corresponding to the general formula <IMAGE> in which R1 denotes a protein or a protein fragment; R2 is COO(C1-3 alkyl) or CO-R7 where R7 is NH2 or an amino acid ester or peptide ester; R3 is H, CH3 or CHO; when R5 and R6 are taken separately, R6 is H and one of R4 and R5 is ethyl and the other is H or OH; when R5 and R6 are taken together with the carbon atoms to which they are attached, they form an oxirane ring and R4 is ethyl, and A is a residue of a bifunctional organic derivative of the maleoylamino acid or maleoyl peptide or maleoylphenoxy type.
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